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Discovery and engineering of a novel peptide, Temporin-WY2, from frog skin secretion, with enhanced in vitro and in vivo antimicrobial efficacy against multi-drug resistant bacteria

Zewen Lu 1 , Halvor Nss 2 , Matthew Gittins 1 , Amit Kishore 3 , Craig Smith 4 , Andy Vail 1 1 Centre for Biostatistics, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, 2 Department of Neurology, University of Bergen, Haukeland University Hospital, Bergen, Norway, 3 Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom, 3 Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom Background and Aims: Traditional prognostic models for stroke outcomes often overlook the dynamic relationship between admission stroke severity and time to admission, limiting predictive efficiency

Torres, S