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Acknowledgements This work was supported by the National Key R&D Program of China (2024YFA0918500)

[DOI] [PMC free article] [PubMed] [Google Scholar] 85.Gao L., Xu Z., Huang Z., Tang Y., Yang D., Huang J., He L., Liu M., Chen Z., Teng Y

However, their activity consumes significant amounts of NAD + , leading to a depletion of cellular NAD + levels and impacting energy metabolism and cell survival 58