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GDF15 regulates the metabolic pathways of macrophages, acquiring an anti-inflammatory function dependent on oxidative phosphorylation, reducing the expression of pro-inflammatory factors, and decreasing the infiltration of monocytes and neutrophils into the liver, thereby alleviating liver inflammation [174, 175]

Fukuda A, Deshpande SB, Shimano Y, Nishino H

They are periodically replaced by a single layer of basal keratinocytes, which proliferate constantly and give birth to cells that ascend toward the skins surface