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Pox virus protein synthesis, by contrast, proceeds within cytoplasmic enclaves inside infected cells, and does not have the benefits of orderly testing of the thermodynamic stability of their protein disulfides, nor is there a reliable, sufficient supply of ATP to support the ongoing synthesis of the three groups of "testing" proteins (protein disulfide isomerases, peptidyl prolyl isomerases and molecular chaperones)

doi: 10.22203/ecm.v025a18

no statin use showing HR [95%CI] of 0.46 [0.40,0.54] and HR [95%CI] of 0.51 [0.45,0.58] (p 1.3

4.3 The role of microbial metabolites in inhibiting the efficacy of immunotherapy While many microbial metabolites enhance immunotherapy efficacy, certain metabolites exert immunosuppressive effects that undermine therapeutic outcomes ( Table 3 , Figure 1B ), with conflicting findings across studies highlighting the need for mechanistic reconciliationoften rooted in shared pathways (e.g., AhR activation, GPCR signaling, metabolic reprogramming) but divergent context (tissue type, concentration, microbiota composition)