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Acknowledgements This work was supported by the National Institute on Drug Addiction (NIDA) of the National Institute of Health (NIH), grants R01DA046487 (D.S., S.M., and J.A.J.), R21DA045884 (S.M

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This process, often referred to as target validation , is a foundational step in early drug development

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Lancet 1:12211225 Hoffman DM, Crampton L, Sernia C, Nguyen TV, Ho KK (1996) Short-term growth hormone (GH) treatment of GH-deficient adults increases body sodium and extracellular water, but not blood pressure

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