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Consequently, despite the clear message of landmark trials such as the Diabetes Control and Complications Trial and the UK Prospective Diabetes Study regarding the need for excellent glycemic control, diabetes remains the leading cause of blindness, renal failure, and amputations

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CBC also increased the levels of cleaved forms of PARP-1, caspase-3, and caspase-9, while downregulating the expression of cyclins, including cyclin D3, cyclin E, and cyclin B1