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Activated Th1 and Th17 cells produce inflammatory products and cytokines that disrupt myelin and axons and activate retained microglia, which in turn generate inflammatory cells that attract more inflammatory cells to the central nervous system (CNS) and perpetuate the inflammatory cascade ( in vitro and in mouse EAE (82)

doi:10.1096/fj.201902076R 599. Zhou Q, Lei Y

The same exosomes also remodel the microbiota-metabolite network, upregulate FXR expression, restore barrier integrity, and reduce colitis inflammation [478], thus linking immune suppression with microecological repair into a closed-loop

Finally, cellular fluorescence intensity, an indicator of ROS (reactive oxygen species) production, was measured using either a FACS Aria III Fusion machine using FITC channel