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Discovery of species-selective and resistance-breaking anticholinesterase insecticides for the malaria mosquito

Cytosolic GSH increases because oxidative stress activates CBS and GCS increasing the flux through the GCS and GS reactions and simultaneously lowering the cytosolic cysteine concentration

Consequent plasma membrane depolarisation leads to opening of voltage-gated Ca 2+ channels and Ca 2+ influx that triggers insulin granule exocytosis [1]