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207 Zinc, copper, and selenium are necessary for production of thyroid hormones, and deficiencies of these minerals may result in hypothyroidism

The increase in circulating homocysteine related to impaired homocysteine metabolism may favor the accretion of a pro-oxidant environment by increasing concentrations of free radicals, by maintaining metal ions in their reduced state suitable for the Fenton reaction, and by changing the redox status of intra- and extracellular thiol groups and, hence, the intracellular redox potential (Mansoor et al, 1993a

Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors

however, the putative effect of anti-hormone antibodies on T4 levels remains to be determined [86]