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13.13 Antinociceptive activity of curcumin Curcumin has shown significant antinociceptive effects in preclinical studies, particularly for neuropathic and inflammatory pain

Studies, predominantly in animal models, have explored its effects on wound healing, tendon and ligament repair, gut health, and neuroprotection

Together, these results demonstrate that neutrophil-intrinsic expression and caspase-3-dependent activation of XKR8 are critical for NET formation in vivo during LPS-induced ALI model

88 A study in children with trichotillomania by the same team, however, found no benefits of NAC at a dose titrated from 600 mg per day to 2400 mg per day, study duration 12 weeks