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Preferably, these antibodies are of human, murine (e.g., mouse and rat), donkey, sheep, rabbit, goat, guinea pig, camel, horse or chicken origin

After an antigen binds to a surface immunoglobulin, a series of events including proliferation and differentiation of that B cell results in secretion of Immunoglobulin that is the specific antibody for that antigen

For example, dual-targeting nanoparticles incorporate two distinct ligands to simultaneously recognize tumor cells and tumor vasculature, thereby improving accumulation and penetration within solid tumors

Furthermore, in hypoxia these PROTACs inhibited tumor migration and induced cancer cells apoptosis