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Wilson's disease is a condition associated with liver and CNS damage, results from genetic deficiency of ceruloplasmin Ceruloplasmin is the major copper-containing protein of the liver and plasma, and functions as an iron oxidizing enzyme (ferroxidase): oxidation of Fe 2+ to Fe 3+ is necessary for the mobilization of stored iron, and nutritional copper deficiency produces anemia

Cysteine and cystine are two interconvertible forms of a sulfur-containing amino acid

The combined use of CQ and bevacizumab can effectively work together to inhibit GBM and control autophagy and angiogenesis in a synergistic manner

10.1007/s12640-010-9223-x Neurotox Res