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Desmosomes are junction complexes, found near adherens junctions, which interact with the cells intermediate filament cytoskeleton and maintain cell mechanical integrity and polarity (1, 15, 35)

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Consistent with our findings with ECIG-flavor-2 in the bronchial model, decreased SCGB1A1, increased SLPI, and increased PI3 levels were detected in the sputum from COPD patients compared to smokers without COPD and/or never smokers 78

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