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Open-label 24-week extension study of edaravone (MCI-186) in amyotrophic lateral sclerosis

Long term clinical safety trials have not been conducted to assess the cardiovascular outcomes of testosterone replacement therapy in men

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FIGURE 9 The core of this toxicity mechanism lies in the depletion of the labile Fe 2+ pool (Figure 5B)without altering total cellular iron (Figure 5A)which triggers a compensatory iron-starvation response (IREB2, TfR1, Ferritin