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Gene Therapies Targeting Mitochondrial Dysfunction in Parkinson's Disease Gene therapy entails the treatment of disease via delivery of a transgene that either replaces or corrects a defective gene or is generally supportive of cells in the disease environment (O'Connor and Boulis, 2015)

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Afterwards, the solution containing the refolded protein was purified via SEC in refolding buffer 2 on the kta Avant or Go system (Cytiva) with a Superdex 75 Increase 10/300 GL or HiLoad 16/600 Superdex 75 pg column (Cytiva) to check for and remove aggregates at a flow rate of 0.5 or 1 mL/min

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