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Furthermore, this integrated molecular signature demonstrated high accuracy in distinguishing TB-DM cases from TB-only, DM-only, and healthy control (without TB and DM) groups in Brazil and was validated in three external cohorts, outperforming signatures derived solely from transcriptomic data (69, 92)

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Metabolic phenotypes are preserved in primary neurospheres To confirm that the metabolic phenotypes are tumour-cell-intrinsic and not a consequence of differences in the TME, we derived 30 primary cell lines from 26 patients with GB (two patients had two cell lines derived from multi-regional tumour sampling)

These results indicate that TLYYH effectively counteracts DSS-induced dysbiosis by restoring the balance between dominant bacterial phyla and promoting microbial homeostasis