aceil l carnitine ACETYL – ROYAL B. VET company Acetyl L L-Carnitine - 60 gélules –

10 The intestine is the primary target organ

Sterile fields must always be kept in sight throughout the entire sterile procedure to be considered sterile

Glossary 1,25-(OH)-VitD 1,25-dihydroxyvitamin D or calcitriol APRIL A Proliferation-Inducing Ligand ALD-DNA Activated Lymphocyte-Derived DNA anti-2GPI Anti-2 glycoprotein I anti-dsDNA Anti-double-stranded DNA Anti-IgE Antibodies that target IgE anti-aPL Anti-phospholipid antibodies anti-RNP Anti-ribonucleoprotein antibodies ANA Antinuclear Antibodies AHR Aryl hydrocarbon receptor (BALB/c) mice Bagg Albino Laboratory-Bred/c mice BAFF B-cell Activating Factor BILAG British Isles Lupus Assessment Group CPSs Capsular polysaccharides CD14 Cluster of Differentiation 14 CD25 Cluster of Differentiation 25 CD4 Cluster of Differentiation 4 CD80 Cluster of Differentiation 80 DC Dendritic Cells SLEDAI Disease Activity Index EBF1 Early B-cell Factor 1 E2A E2A Transcription Factor ESR Erythrocyte sedimentation rate ER- Estrogen receptor-beta ECPS Extracellular polysaccharides EVs extracellular vesicles F/B ratio Firmicutes/Bacteroidetes ratio Foxp3 Forkhead Box Protein P3 GPCRs G protein-coupled receptors GATA3 GATA Binding Protein 3 HDACs Histone Deacetylases HCT116 Human Colorectal Carcinoma Cell Line 116 HLA-DR Human Leukocyte Antigen DR isotype anti-RG autoantibodies IgG antibodies targeting antigens from the gut bacterium Ruminococcus gnavus (RG) IgA Immunoglobulin A IgE Immunoglobulin E IgG1 Immunoglobulin G1 IDO Indoleamine 2,3-dioxygenase IFN- Interferon-gamma IRF4 Interferon Regulatory Factor 4 IL-1 Interleukin-1 beta IL-4 Interleukin-4 IL-10 Interleukin-10 IL-12 Interleukin-12 IL-13 Interleukin-13 IL-17 Interleukin-17 IL-23 Interleukin-23 IAP Intestinal alkaline phosphatase LPS Lipopolysaccharides LTA Lipoteichoic acid M1, M2 Macrophage subsets mRNA Messenger Ribonucleic Acid MAMPs Microbe-associated molecular patterns MUC2 Mucin 2 MRL/lpr Murphy Roths Large/Lymphoproliferative Netosis Neutrophil Extracellular Trap formation NETs Neutrophil Extracellular Traps NLRs NOD-like receptors NF-B pathway Nuclear Factor kappa-light-chain-enhancer of activated B cells NZBWF1 mice New Zealand Black/White F1 hybrid mice NZW/LacJ mice New Zealand White/LacJ mice PAX5 Paired Box Protein 5 PRRs Pattern recognition receptors PGN Peptidoglycan PBMCs Peripheral blood mononuclear cells PMA Phorbol 12-myristate 13-acetate PD-L1 Programmed Death-Ligand 1 ROS Reactive Oxygen Species RG Ruminococcus gnavus Tregs Regulatory T cells CD4+CD25+ Foxp 3+ Tregs Regulatory T cells defined by the co-expression of: CD4, CD25, Foxp3 RORt Retinoic Acid Receptor-Related Orphan Receptor Gamma t RLRs RIG-I-like receptors SCFAs Short-Chain Fatty Acids STAT3 Signal Transducer and Activator of Transcription 3 SIGNR3 Specific Intercellular adhesion molecule-3-Grabbing Non-integrin Receptor 3 SLPs Surface proteins SLE Systemic Lupus Erythematosus T-bet T-box transcription factor TBX21 Tac Tacrolimus Th1, Th2, Th17 T helper cell subsets TA Teichoic acid TLRs Toll-like receptors TGF- Transforming Growth Factor-beta TNF- Tumor Necrosis Factor-alpha CpG DNA Unmethylated cytosine-phosphate-guanine DNA VDR Vitamin D Receptor ZO-1 Zonula Occludens-1 (ZO-1) A

This could be because aberrant copper metabolism gradually accumulates from the liver into other tissues over time, primarily harming the cornea and nervous system