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Description

Among the four, three new interfacial salt bridges (Figures 3 and 4) were found to be formed due to the missense mutations introduced into semaglutides backbone (including in particular L23B R), whereas only one interfacial salt bridge (yellow row in Table 4) was found to be formed and the same as the salt bridge (Table 1) identified in PDB entry 4ZGM [24, 35]