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Tsai-Turton & Lauderer in their publication in the journal Endocrinology reported that evidence proves oxidative stress (inflammation) induces apoptosis (cell death) in preovulatory follicles and that the antiapoptotic (preventing cell death) effect of FSH is mediated in part by stimulation of follicular glutathione (GSH) and suppression of ROS production

Nitric oxide also plays a role in iron trafficking because it mimics the consequences of iron starvation and triggers iron uptake by cells

doi: 10.3390/ijms20184559 Pubmed Abstract CrossRef Google Scholar Keywords thiamine, riboflavin, niacin, pyridoxine, folate, cobalamin, complex B vitamins, neuropsychiatric manifestations Citation Han A, Almeida L, Anand N, Salloum IM, Kanaan S, Gadad BS and Daher JPL (2025) Exploring neuropsychiatric manifestations of vitamin B complex deficiencies

Liver is the major site of HDL synthesis and interestingly NADP + correlated positively with liver markers alanine transaminase (ALT), aspartate transferase (AST) and gamma-glutamyl cysteine (Fig