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Key alterations include the accumulation of fragmented collagen fibrils in the dermis 44 , an elevated type I/III collagen ratio along with AGEs deposition in the myocardium 45,46 , and the breakdown of elastin into bioactive peptides in arterial walls 47

Another epidemiological study in different regions is mentioned in (Table 2 )

The principle behind this strategy is intended to cause a sudden release of stored iron from ferritin within cancer cells that would fuel the Fenton reaction and lead to ferroptosis (Fig