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Disclosure of interest: Sheng-Feng Sung, Cheng-Yang Hsieh, Hsin-Yi Yang, Ching-Fang Tsai, Chen-Wen Fang: nothing to disclose E-Posters - RISK FACTORS - PRIMARY AND SECONDAR PREVENTION 05.00 - RISK FACTORS AND PREVENTION (PRIMARY AND SECONDARY) - 05.02 - SECONDARY PREVENTION P2472 - ESOC25-417 CHANGES IN PLATELET REACTIVITY AFTER DOSE REDUCTION IN PATIENTS WITH ENHANCED RESPONSE TO CLOPIDOGREL: A PAIRED ANALYSIS Jin Soo Lee 1 , Hyeon Min Lee 1 , Bok Seon Yoon 1 , Seong-Joon Lee 1 1 Department of Neurology, Ajou University School of Medicine, Ajou University Medical Center, Suwon, South Korea Background and Aims: While clopidogrel resistance is a well-known concern in cardiovascular and cerebrovascular disease prevention, some patients exhibit enhanced response to standard dosing, potentially increasing bleeding risk