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Data Animal Data In pregnant rats given daily subcutaneous doses of zoledronic acid of 0.1, 0.2, or 0.4 mg/kg during organogenesis, fetal skeletal, visceral, and external malformations, increases in pre-and post-implantation loss, and decreases in viable fetuses and fetal weight were observed at 0.2 and 0.4 mg/kg/day (equivalent to 2 and 4 times the human 5 mg intravenous dose, based on AUC)

Because many drugs are excreted in human milk, caution should be exercised when somatropin is administered to a nursing woman

It is a dry chemical system that may include residual salts, counterions, buffers, and other components left behind after processing

PMID: 27499788