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This distinctive temporal feature not only directly limits fertility [4, 5], but is also strongly associated with various age-related conditions, including cardiovascular disease, osteoporosis, and cognitive impairment, thereby posing a substantial public health challenge [6,7,8]

Furthermore, pharmacological induction of catecholamine signalling or acute fasting was shown to trigger the formation of crown-like structures 45

A significant contributor to this resistance is the immunosuppressive TME, where metabolites like lactate play a detrimental role ( In this review, we systematically dissect the glycolysis-lactylation axis as a central metabolic-epigenetic driver orchestrating broad-spectrum therapeutic resistance

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