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All these characteristics could negatively affect immune response, disrupt immune cells and drug diffusion into the tumor

Furthermore, Guilin Chang et al.s study, published in 2019, included only nine studies on the elderly population and did not consider young and middle-aged IS patients ( 2 Materials and methods The study follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (Moher et al., 2009)

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2 What is the main cause of male infertility