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Recent drug discovery strategies are based on two criteria: first, compound structures that are distinct from bicalutamide and enzalutamide to avoid cross-resistance and, second, compounds that retain antagonist properties even for known AR mutant proteins that adopt agonist conformations when bound to current AR antagonists (also known as pan-antagonists)

In some patients with COVID-19, damage to organs such as muscles has been reported, resulting in increased CPK and LDH enzymes

Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias

Tauson, R., Wahlstrm, A., Abrahamsson, P