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Conversely, hypomethylation of CHGA and LINGO1 in the prefrontal cortex is linked to increased expression and abnormalities in neuroendocrine function, myelination, and neurodevelopment (Ueda et al., 2021)

The proposed mechanism described in papers that were later retracted is that it potentiates hepatocyte growth factor (HGF) signaling at the c-Met receptor, driving dendritic spine formation and synaptogenesis

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Pyridoxine-dependent epilepsy and antiquitin deficiency resulting in neonatal-onset refractory seizures