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The benefits begin to be felt in a concrete way between the fourth and sixth session in a recommended program of about twelve treatments in six weeks (two sessions per week) with periodic maintenance calls ideally to be practiced every three to four weeks

doi:10.1242/jeb.00241 ^ a b c d e f g h i j Atkins P.W., Ratcliffe R.G., Wormald M., De Paula J

Different studies have also demonstrated that melatonin suppresses acrolein-induced IL-8 production in human pulmonary fibroblasts (Kim et al., 2012) and inhibits TGF-1-induced fibrogenesis in mouse lung fibroblasts (Zhao et al., 2018)

And although the pain you feel is due to the constant firing of your neurons, its the nearby immune cells that are likely to blame