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Together, this functional data indicates that inhibition of oxidative phosphorylation, cell cycle alterations, and mitigation of radiation-induced G2/M arrest may contribute to metformin-mediated radiosensitisation in CRC

Among the most relevant studies conducted in the last year, Shen and colleagues recently validated SDC2 and SHOX2 DNA methylation hotspots across different biological matrices (tissue, blood, and stool samples) as diagnostic biomarkers for the early detection of CRC [145]

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For long-standing conditions, a minimum of 3 treatments is required taken every two to 4 weeks, to ensure the best outcome is achieved