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This sleep phase may be understood as serving a restorative and therapeutic role in the central nervous system

With the onset of IDD, IVD, especially NP, undergoes a progressive dehydration due to proteolytic cleavage of aggrecan together (Karppinen et al., 2011), a substantial reduction of resident cell viability (Vergroesen et al., 2015)

These findings suggest that while FOXO4 is involved in the senescence pathway, it also plays a role in maintaining the viability of senescent Leydig cells by suppressing their apoptotic response, which could contribute to the accumulation of senescent cells [1]