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The tumor size was measured twice per week, and the tumor volume was calculated according to the flowing equation: volume = length width 2 /2

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Taken together, in the current study, the combination therapy of SE with AST and PHA exerted more favorable actions in all the measured behavioral outcomes, neurotransmitters levels, biochemical parameters, together with histopathological findings, compared to any other group in this study

[] Ascorbic acid is a vinylogous carboxylic acid, which consists of the vinyl double bond that transports electron pairs between the hydroxyl and carbonyl groups as shown in Figure 9