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Glutathione's ability to convert eumelanin (darker pigment) to pheomelanin (lighter pigment) is the rationale behind its use for skin-lightening purposes

The antioxidant effect of DEC-containing serum on pigmented full-thickness human skin model To evaluate the antioxidant potential of the DEC-containing serum under oxidative stress induced by MGO and UV irradiation, we analyzed ROS levels using fluorescence staining and measured key antioxidant markersincluding Nrf2, SOD, and GSH-Px1through semi-quantitative immunofluorescence in a pigmented full-thickness human skin model

Vinod C, Jagota A (2017) Daily Socs1 rhythms alter with aging differentially in peripheral clocks in male Wistar rats: therapeutic effects of melatonin