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It has been reported that tumor-surrounding adipocytes exhibit an distinct phenotype comparing to normal adipocytes, which is characterized by upregulated beige/brown adipose markers and increased catabolism and the release of metabolites, including lactate, free fatty acids, pyruvate, and ketone bodies

In mammalian studies ( At present, the neurobiological mechanism of PTSD has not been confirmed, and the research directions mainly include four aspects: (1) Genes involved with monoamine and the hypothalamic-pituitary-adrenal (HPA) axis function have been examined extensively in epigenetic and genetic studies of PTSD risk and separately in studies of disease risk and response to treatments for mood disorders (Zannas et al., 2015

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Acknowledgements This study was financially supported by the China Agriculture Research System of MOF and MARA (No