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The therapeutic effects of SAM are associated with the downregulation of the ERK1/2 and STAT3 signaling pathways, both of which are involved in the survival, proliferation, migration, and invasion of cancer cells

Since GMB can contribute to ammoniagenesis, we tested if endurance exercise alters the gut microbiome to favor SCFA production and alter ammoniagenic bacteria in ab mouse model of hyperammonemia of liver disease

In chronic CCl4/HFD-induced liver injury, HSYA ameliorated serum biochemical indicator, reduced mRNA expression levels of pro-fibrotic factors and elevated hepatoprotective factors, which revealing that PPAR- and p38 MAPK signaling play pivotal roles in the prevention of liver fibrosis (Liu et al., 2014)