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Description

PLoS One 8 , e76057, (2013)

(2017) 12:e0181350

Respiratory symptoms occur in about 40% of people with dermatomyositis, and in these people, the symptoms may slowly progress, contributing to increased morbidity and mortality

As has been reported with grapefruit juice, time-dependent inhibition of CYP3A can result in irreversible loss of protein, requiring de novo synthesis to restore enzyme activity over a time course dictated by the half-life of CYP3A protein