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Description

We developed benzoxazole compounds with aromatic (phenyl, naphthyl, and biphenyl groups) and heteroaromatic (pyridine, pyrrole, furan, and thiophene) groups in the 2-position of benzoxazole to increase PAS binding potential for AChE in our fragment-based strategy

Additionally, the potential of AS-IV to mitigate toxicity when co-administered with anticancer drugs is explored, highlighting its broader therapeutic applicability and role in optimizing polypharmacy strategies for improved patient outcomes (Figure 2)