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In addition, research has shown that ROS produced in the mitochondria during T-cell activation affects Ca 2+ homeostasis in a concentration-dependent manner, activating the TF NFAT (107, 131)

Answers and questions from the KvAP structures

Currently, the small-molecule compound KU-57788 (also named NU7441) is a specific inhibitor of DNA-PKcs and is commonly used as a research tool for targeting DNA-PKcs function [15]