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Finally, we showed that pharmacological inhibition of the thioredoxin system by the chemotherapeutic drug arsenic trioxide (ATO) enhanced MTX cytotoxicity in vivo against one out of four primary human ALL cells, suggesting a novel therapeutic rationale to be further explored against ALL

They give rise to amplifying progenitors (type C cells), which, in turn, mostly produce neuroblasts that migrate along the rostral migratory stream to the olfactory bulb, where they differentiate into olfactory interneurons (Lois and Alvarez-BuyIIa, 1994

For controlled skin studies, topical application removes the confounders introduced by injection no injection site reactions, no systemic distribution diluting local concentration, no injection technique variability across research subjects

The 1 mg community standard is the conservative entry point documented in community protocols