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Regular supplementation can improve focus, mental clarity, and overall mood, reducing symptoms of anxiety and depression linked to B12 deficiency

The precise underlying cause of Mnire disease is not yet clear

The intracellular concentrations of vitamin B12 can be inferred through the total plasma concentration of homocysteine, which can be converted to methionine through an enzymatic reaction that uses 5-methyltetrahydrofolate as the methyl donor group

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