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reported that HIF-1 can regulate the malignant progression of GBM under hypoxic conditions and that hyperbaric oxygen significantly inhibits HIF-1 expression, increasing the sensitivity of GBM cells to chemotherapy ( TGF-1 induces HIF-1 overexpression and nuclear accumulation by upregulating NOX4 expression and ROS production, ultimately leading to metabolic reprogramming and promoting EMT

Therefore, terpenes can be considered reliable agents that promote cell membrane damage and exert bacteriostatic effects (Khan et al., 2020

Effect of polygonum cuspidatum and hawthorn on anti-atherosclerosis unstable plaque

Thalidomide therapy and polyneuropathy in myeloma patients