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In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]

They all say pretty much the same thing: that they recognized immediately that the official rescue services were overwhelmed and that they had no choice

So when people talk about estrogenlike during discussions about how perimenopause impacts your hormones or about hormone therapytheyre likely referring to estradiol