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Reportedly, the blood concentration of pirfenidone 5-carboxy-pirfenidone metabolite excreted through the kidneys significantly increases in patients with severe renal impairment (area under the curve of mild, moderate, and severe renal impairment was 49.3, 100, and 168 mghr/L, respectively

The mean decline in eGFR at 5 years compared to baseline did not significantly differ between groups (KIGS, 5.8 ml/min/1.73 m 2

Encouraged by the results, we adopted a subcutaneous tumorigenesis mouse model

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