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Description

The brainstem belongs to the evolutionally ancient parts of the brain and includes the midbrain (mesencephalon), bridge (pons) and medulla oblongata

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Inouye S, Uchida K, Nishiyama Y, Hasumi Y, Yamaguchi H, Abe S

However, TMAO insult alone was not sufficient to convert renal fibroblasts to myofibroblasts requiring synergy with a preexisting pathological state, i.e., pro-fibrotic signaling (second-hit) in the form of TGF-1 stimulation, the most prominent pro-fibrotic cytokine 46