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It also influences cardiovascular homeostasis by activating the Ang II type 1 receptor, mainly found in cardiovascular cells [113]

Instead, it is mediated through the systemic administration of CB 1 agonists acting on peripheral CB 1 receptors, resulting in hypotension due to the inhibition of noradrenaline release from postganglionic sympathetic neurons ( locus coeruleus through the vagus nerve (see Figure 1)

Furthermore, novel therapeutic approaches have been developed to target signaling pathways in OCSCs (108)

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