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Acknowledgements The present study was supported by the Research Council of Norway [grant number: 214329]

These studies show that GCK can treat RA in many ways, and it is an effective drug for treating RA

Patients in combination therapy group received PEG-IFN-2b for 12 weeks followed by TDF add-on for 36 weeks, TDF monotherapy group received TDF for 48 weeks and control group received follow-up only (Figure 1A)