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Individuals who may benefit include those experiencing fatigue associated with oxidative stress or inadequate cellular recovery, people with compromised liver function or high toxic exposure, those dealing with chronic inflammation or frequent illness, athletes seeking to support faster recovery from intense training, and individuals with age-related concerns where declining glutathione synthesis is a documented phenomenon

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However, under pathological conditions, ESM1 is aberrantly expressed and interacts with its substrate proteins to promote abnormal cell adhesion, proliferation and angiogenesis (5)