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Nature 575:693698 Kim R et al (2022) Ferroptosis of tumour neutrophils causes immune suppression in cancer

By boosting glutathione levels, either through supplementation or intravenous therapy, patients with Lyme disease may experience enhanced immune function, reduced inflammation, and improved overall well-being, aiding in the recovery process and potentially alleviating some of the debilitating symptoms associated with this chronic condition

(2024) Ergothioneine ameliorates metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) by enhancing autophagy, inhibiting oxidative damage and inflammation

The di-tryptophan cross-link may weaken the non-covalent bonds between the SOD1 monomers, triggering enzyme unfolding, oligomerization, and aggregation (Coelho et al., ALS-associated SOD1 mutants produce free radicals (ONOO or OH ) and some mutants lose its catalytic activity, which in turn produces highly unstable intermediate products and tyrosine (Abe et al., 2006)