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like GLP-1, it is secreted after nutrient intake and contributes to glucose-dependent insulin secretion, but it also has distinct effects on adipose tissue and lipid handling that GLP-1 does not replicate

24 Secondly, activated Akt phosphorylates forkhead box O1 (FOXO1), a transcription factor upregulating gluconeogenesis rate-limiting enzyme such as phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), and translocate it from nucleus to cytoplasm, which inactivate its transcriptional activity, thus inhibiting gluconeogenesis

Individuals rely more on cognitive resources to monitor and control knee movements consciously, leading to increased mental fatigue and slower motor responses during complex tasks

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