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Abstract The leptomeninges present a challenging tumour microenvironment with cells receiving low levels of nutrients and oxygen from cerebrospinal fluid (CSF), however these metabolic constraints are yet to be exploited therapeutically

Chen WC, Chang YS, Hsu HP, Yen MC, Huang HL, Cho CY, et al

In this review, the biochemical basis of oxidative stress in ASD is examined, the mechanistic understanding of antioxidant-based interventions is assessed, and the structureactivity relationships that dictate their therapeutic value are discussed

Circadian misalignment may further potentiate CTGF overexpression, compounding fibrotic injury through sustained activation of profibrotic gene programs