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Alcohol disrupts this protective communication between macrophages and hepatocytes, inhibiting ISG induction and increasing HBV replication, which weakens innate antiviral immunity ( Recent single-cell RNA sequencing (scRNA-seq) studies have further clarified macrophage heterogeneity and functional states in the context of HBV infection and alcohol exposure

Environ Inter 31:739753 Bai TH, Li Y, Ma FW, Shu HR, Han MY (2009) Exogenous salicylic acid alleviates growth inhibition and oxidative stress induced by hypoxia stress in Malus robusta Rehd

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For instance, thalidomide, which was globally banned in 1960s due to its teratogenic properties, was approved for treating leprosy in 1998 and for multiple myeloma as well in 2006