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Effects on skin of Stichopus japonicus viscera extracts detected with saponin including holothurin A: Down-regulation of melanin synthesis and Up-regulation of neocollagenesis mediated by ERK signaling pathway

Generally, about 8.7% of people between the ages of 45 to 85 are affected by AMD, with a smaller percentage (0.4%) having an advanced form of the disease

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The latter peculiar feature may be adopted for drug delivery applications since the release can be modulated and programmed by a specific pH stimulus